en POLSKI
eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2019
vol. 25
 
Share:
Share:
abstract:
Original paper

Skin microvascular circulation is not affected by diabetes duration in young patients with non-complicated type 1 diabetes mellitus

Melanie Wielicka
1
,
Jolanta Neubauer-Geryk
2
,
Agnieszka Brandt-Varma
3
,
Małgorzata Myśliwiec
3
,
Leszek Bieniaszewski
2

  1. Medical University of Gdansk, Gdansk, Poland
  2. Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gdansk, Gdansk, Poland
  3. Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk, Poland
Pediatr Endocrinol Diabetes Metab 2019; 25 (4): 183-187
Online publish date: 2019/12/30
View full text Get citation
 
PlumX metrics:
Introduction
Skin microcirculation is recognized as an appropriate model to use when investigating the relationship between cardiovascular risk factors and microvascular function. It is currently a matter of debate whether studies on skin microcirculation in young type 1 diabetic patients without existing microangiopathy may be helpful in identifying subjects with impaired endothelial function.

Aim of the study
To evaluate the potential changes in skin microcirculation of patients up age of 18 years using capillaroscopy, post reactive hyperaemia (PORH) and venous occlusion (VO) tests, and to establish the relationship between those changes and disease duration and metabolic control in patients with type 1 diabetes.

Material and methods
Study group consisted of 112 pediatric patients aged 8.4–18.0 years, with a median age of 14.95 years. The median diabetes duration and age at onset were 5 years and 9.6 years, respectively. The median HbA1c in the studied group was 7.6% at the time when the microcirculation was being examined. Capillaroscopy studies were focused on type 1 diabetic patients and employed non-selective stimuli such as the PORH and VO tests. The relative area covered by capillaries (coverage) was measured before the testing and again after the PORH and VO tests.

Results
The analysis revealed that none of the skin microcirculation indices correlated significantly with patient age, diabetes duration or metabolic control.

Conclusions
In young patients with uncomplicated type 1 diabetes mellitus skin microcirculation function is not dependent on age, disease duration or metabolic control.

keywords:

diabetes mellitus type 1, skin microcirculation, capillaroscopy, diabetes duration, metabolic control


Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.