en POLSKI
eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
3/2017
vol. 23
 
Share:
Share:
abstract:
Original paper

Coexisting psoriasis affects the clinical course of type 1 diabetes in children

Arkadiusz Michalak
,
Marta Koptas
,
Aleksandra Świercz
,
Krystyna Wyka
,
Anna Hogendorf
,
,
Agnieszka Szadkowska
,
Wojciech Młynarski
,
Wojciech Fendler

Pediatr Endocrinol Diabetes Metab 2017;23,3:139-145
Online publish date: 2017/12/14
View full text Get citation
 
Introduction. Literature reports link psoriasis with insulin resistance characteristic for type 2 diabetes. However, this condition may also affect the clinical course of type 1 diabetes (T1D). Aim. To investigate whether children with type 1 diabetes mellitus (T1D) and psoriasis have a different course of diabetes. Methods. We evaluated patients diagnosed with T1D in the years 2002-2011 for the presence of psoriasis and matched them 1:10 with T1D-only patients by sex and duration of diabetes using propensity score. We collected T1D-onset parameters and metabolic control surrogates from six months after T1D diagnosis. Results. We identified 14 patients with psoriasis and matched 140 controls, of whom 129 (68 boys) were eligible for the analysis. At onset T1D+psoriasis patients showed higher concentration of C-peptide than controls (median: 0.38ng/ml vs 0.15ng/ml, p=0.02). Six months later, they had non-significantly lower HbA1c (6.0 vs 6.6%, p=0.11), TC (143mg/dl vs 159mg/dl, p=0.14) HDL (54.5mg/dl vs 59mg/dl, p=0.11). Conclusions. Patients with T1D and psoriasis present higher endogenous insulin secretion at T1D onset and a tendency for better glycemic control during the first 6 months.
keywords:

type 1 diabetes, children, psoriasis, c-peptide


Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.